The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Gastrointestinal Manifestations ... Gastrointestinal #Complications ... #pathophysiology ... #signs #symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Musculoskeletal Manifestations ... Musculoskeletal #Complications ... #pathophysiology ... #signs #symptoms
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... / Symptoms / Complications ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis ... #signs #symptoms
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs ... / Symptoms / Complications ... Retinoblastoma #pathophysiology ... #ophthalmology ... #diagnosis #signs
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Mucocutaneous Manifestations ... Mucocutaneous #Manifestations ... #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Opioid Withdrawal: Clinical Findings and Complications
Note: Opioid withdrawal can be extremely uncomfortable, but is rarely life-threatening
Opioid Withdrawal ... Clinical Findings and Complications ... Note: Opioid withdrawal ... #Opiate #Pathophysiology ... #Diagnosis #Signs
Xeropthalmia: Pathogenesis and Ocular Manifestations

Decr Visual pigment -> Keratinization, thickening & non-wetting of the conjunctiva
Pathogenesis and Ocular Manifestations ... #Xeropthalmia #pathophysiology ... #ophthalmology ... #diagnosis #signs
Upper Urinary Tract infection (UUTI): Pathogenesis and Clinical Findings

Predisposing Factors:
 - Immunocompromised, Diabetes,
 - Elderly, Female
usual defense system ... lower tract: As a complication ... UrinaryTractInfection #UUTI #Pathophysiology ... #Signs #Symptoms
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
Patient's immune system ... cells recruited Complications ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
> Keratoconus Signs ... / Symptoms / Complications ... • Rizutti's Sign ... #Keratoconus #pathophysiology ... #ophthalmology