The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
fraction • HTN #GrowthHormone ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
etiology Signs/Symptoms ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs ... #diagnosis
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin #Inhibitors #Pathophysiology ... #Pharmacology # ... SideEffects #Psychiatry #Diagnosis ... #Signs #Symptoms
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology # ... SideEffects #Psychiatry #Diagnosis ... #Signs #Symptoms
Pediatric Parasomnias and Nightmares: Pathogenesis and clinical findings

Parasomnias - Micro-arousal episodes during SWS ->
Intense activation of
Pediatrics #Peds #pathophysiology ... #symptoms #pharmacology ... #diagnosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Injury #Syndromes #diagnosis ... #pathophysiology ... #signs #symptoms ... #orthopedics #neurology
Erectile Dysfunction: Pathogenesis

Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
and rigidity Endocrinologic ... #Dysfunction #Pathophysiology ... #Urology #Diagnosis
Varicocele: Pathogenesis and clinical findings
Primary:
 - Anatomically: the left spermatic vein drains into the left renal
#Varicocele #Pathophysiology ... #Signs #Symptoms ... #Urology #Diagnosis
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings

Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Incontinence #Mixed #Pathophysiology ... #Signs #Symptoms ... #Urology #Diagnosis