The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
etiology Signs/Symptoms ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
A good mnemonic ... Signs / Symptoms ... #SideEffects #endocrinology ... #mnemonic #GLFTAP ... #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Borderline Personality Disorder: Pathogenesis and Clinical Findings
Behavioral Traits:
 • Unstable Relationships - Alternating extremes of idealization
experienced BPD Mnemonic ... the above with symptoms ... Diagnosis #Psychiatry #Criteria ... #Signs #Symptoms ... #Mnemonic #AMSUICIDE
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... diagnosis #signs #symptoms ... #endocrinology ... #pathophysiology
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Clinical Findings Symptoms ... included in DSM 5 criteria ... suicide Other Symptoms ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... #FeedbackLoop #endocrinology ... #pathophysiology
Schizotypal Personality Disorder (SPD): Pathogenesis and clinical findings
Cognitive-Perceptual
 • Magical thinking - Belief in paranormal or
familiarity SPD Mnemonic ... Diagnosis #Psychiatry #Criteria ... #Signs #Symptoms ... #Mnemonic #MEPECULIAR
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
have either 26 symptoms ... 2 settings - Symptoms ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... signs #psychiatry #criteria
Dependent Personality Disorder (DPD): Pathogenesis and Clinical Findings
 • Difficulties with Activities - Initiation Of projects
themselves DPD Mnemonic ... Diagnosis #Psychiatry #Criteria ... #Signs #Symptoms ... #Mnemonic #RELIANCE