The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis symptoms orthopedics complications gh growthhormone msk acs anorexianervosa anterior arteritis compartmentsyndrome dislocation erythematosus feedbackloop gastrointestinal hyperthyroidism injury lupus
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... Carpal Tunnel Syndrome ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... lipid • GH excess ... #FeedbackLoop #endocrinology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... Anterior Cord Syndrome ... • Central Cord Syndrome ... weakness and #Acute ... pathophysiology #signs
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Vasculitis -> Acute ... - Budd Chiari Syndrome ... pathophysiology #signs
Acute Compartment Syndrome • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
Acute Compartment ... Syndrome • Crush ... disperse. => Excess ... compartment pressure #Acute
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
joint => Force exceeds ... to glenoid -> Acute ... Dislocation #Diagnosis #signs
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Non-specific Acute-phase ... joint capsule exceeds ... Extra-articular signs ... pathophysiology #signs
Takayasu’s Arteritis: Pathogenesis and clinical findings - Fatigue, weight loss, low grade fever, arthralgias - Incr
, Incr risk of Acute ... Coronary Syndrome ... Vasculitis #Diagnosis #Signs
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
hypogonadism - acquired ... - Lethargy or Excess ... pathophysiology #diagnosis #signs
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