The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms immunology pharmacology psychiatry sideeffects anaphylaxis endocrinology hypersensitivityreaction inhibitors menstrualcycle msk orthopedics acs anticonvulsants comparison compartmentsyndrome complications erythematosus
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... Complications: • Acute ... #Immunology #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... Allergic reaction ... Initial exposure to allergen ... Stevens-Johnson Syndrome ... #Immunology #pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
Mood Stabilizers: Mechanism ... constipation • Allergic ... Stevens-Johnson Syndrome ... MoodStabilizers #Mechanism ... #SideEffects #Pathophysiology
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
Reuptake Inhibitors: Mechanisms ... • Serotonin Syndrome ... SSRI Withdrawal Syndrome ... Serotonin #Inhibitors #Pathophysiology
Fecal Incontinence - Pathogenesis and Complications Continence mechanisms are impaired • Local neuronal damage • External and
Complications Continence mechanisms ... impairment Continence mechanisms ... irritable bowel syndrome ... Incontinence #geriatrics #pathophysiology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... Anterior Cord Syndrome ... • Central Cord Syndrome ... weakness and #Acute ... #diagnosis #pathophysiology
Acute Compartment Syndrome • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
Acute Compartment ... Syndrome • Crush ... local signalling mechanisms ... compartment pressure #Acute ... CompartmentSyndrome #ACS #pathophysiology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Acute onset of skin ... exposure to a likely allergen ... exposure to known allergen ... symptoms in the acute ... #Anaphylaxis #pathophysiology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Inhibitors(SNRIs): Mechanisms ... Vomiting Serotonin Syndrome ... SerotoninNorepinephrine #Inhibitors #Pathophysiology
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Vasculitis -> Acute ... - Budd Chiari Syndrome ... Complications #pathophysiology
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