The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis pathophysiology signs symptoms complications sle allergy arteritis erythematosus giantcell systemic avascularnecrosis classification cranialarteritis definitions gastrointestinal giantcellarteritis hypersensitivity hypersensitivityreaction immunology
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... fever, Urticaria, Allergic ... • Ex: Systemic Lupus ... #Allergic #Reactions
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... palpation - Vasculitic ... #GiantCell #Temporal ... Signs #Symptoms #Vasculitis
Giant Cell (Temporal) Arteritis: Clinical findings and Complications Signs/Symptoms: - Headache (usually constant, superimposed by waves
Giant Cell (Temporal ... palpation - Temporal ... #GiantCell #Temporal ... Symptoms #diagnosis #Vasculitis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Systemic #Lupus
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Esp. humeral and femoral ... #Systemic #Lupus
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
: • Systemic Lupus ... HypersensitivityReaction #Allergy
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... Phenomenon #Lupus
Giant Cell Arteritis (Polymyalgia Rheumatica and Cranial Arteritis): Pathogenesis and Clinical Findings - Morning Stiffness (>1
Weight Loss #Temporal ... Symptoms #Diagnosis #Vasculitis
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
blood supply & the femoral ... therapy - Lupus
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