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diagnosis differential nephrology acute renal urine ain blood bloodsmear borrelia clinical crystals dipstick dysuria glucosuria injury interstitial kidney kidneyinjury leucocyteesterase
Algorithmic Approach to Acute Interstitial Nephritis When to suspect AIN? (not sensitive) • AKI, AKD, rapidly progressive
Algorithmic Approach ... sterile pyuria, WBC casts ... eosinophiluria, microscopic ... hematuria, mild ... proteinuria, granular casts
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... urine sediment by microscopy ... syndrome: • ... : - RBC casts ... microscopic and
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... Differential Diagnosis Algorithm ... cells on urine microscopy ... RBCs and/or RBC casts ... with polyangiitis/microscopic
Causes of Dysuria - Differential Diagnosis Algorithm Pyuria - Leukocytes on Dipstick/Microscopy - Bacteriuria & Hematuria -
Differential Diagnosis Algorithm ... Leukocytes on Dipstick/Microscopy ... Bacteriuria & Hematuria ... Pyelonephritis - WBC Casts ... Leukocytes on Dipstick/Microscopy
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... • Hepatorenal syndromes ... Epithelial cell casts ... Obstruction • Cast ... polyangiitis /microscopic
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Workup Algorithm ... dipstick, urine microscopy ... osmolarity If cause ... • Cardio-renal syndrome ... #Workup #Algorithm
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Differential Diagnosis Algorithm ... • Fanconi's syndrome ... sediment - WBC/RBC casts ... polyangiitis (GPA) / microscopic ... #Causes
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), MPA (microscopic ... EGPA) • Renal: (AKI ... FINDINGS: • U/A: microscopic ... or gross hematuria ... , RBC casts, low
Urinalysis & Urine Sodium Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused exclusively
Microscopic exam ... • Urinary casts ... Kidney Injury (AKI ... leucocyte-esterase #urine #UNa #casts ... #glucosuria #hematuria
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
resolved after 2-3d ... Northeast Africa with cases ... Several cases have ... Syndrome: 3d of ... recurrentis #BloodSmear #microscopy
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