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diagnosis differential nephrology acute clinical injury msk pulmonary renal urine ain ana anca antibodies antibody antineutrophil antinuclear blood bloodsmear borrelia
Algorithmic Approach to Acute Interstitial Nephritis When to suspect AIN? (not sensitive) • AKI, AKD, rapidly progressive
Algorithmic Approach ... sensitive) • AKI ... sterile pyuria, WBC casts ... eosinophiluria, microscopic ... proteinuria, granular casts
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... • Hepatorenal syndromes ... Epithelial cell casts ... polyangiitis /microscopic ... #Causes
Urine Microscopy - Casts Acellular Casts • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... - Casts Acellular ... Casts • Hyaline ... suggestive of nephrotic sydnrome ... #Urine #Microscopy
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... disease - Alport syndrome ... pain hematuria syndrome ... hematuria: - RBC casts ... • Nutcracker syndrome
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Workup Algorithm ... dipstick, urine microscopy ... osmolarity If cause ... Abdominal compartment syndrome ... • Cardio-renal syndrome
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Fanconi's syndrome ... sediment - WBC/RBC casts ... polyangiitis (GPA) / microscopic ... #Causes
Urinary Casts and Disease Associations Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... Fatty - Nephrotic syndrome ... #Differential #Microscopy
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Causes of Hemoptysis ... Differential Diagnosis Algorithm ... Goodpasture's Syndrome ... polyangiitis / microscopic ... #Causes #Pulmonary
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... age • 22 and 45 cases ... (CML) • Felty Syndrome ... Myelodysplastic Syndrome
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal Syndromes ... Pulmonary Renal Syndromes ... EGPA) • Renal: (AKI ... hematuria, RBC casts ... Pulmonary #Renal #Syndromes
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