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differential management rheumatology symptoms algorithm aplastic erythematosus lupus sle systemic mds myelodysplastic pancytopenia rheumatoid syndrome treatment arteritis autoantibodies cell chronic
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... vs Hypocellular MDS ... #Aplastic #Anemia ... #diagnosis #oncology ... #hematololgy
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Deficiency • MDS ... #Macrocytic #Anemia ... #differential #diagnosis ... #algorithm #hematology ... #workup
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Diagnosis: • Pancytopenia ... Can progress to MDS ... #diagnosis #management ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... cytopenias (usually anemia ... Myelodysplastic #Syndrome #MDS ... #treatment #hematology ... #oncology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... and Differential Diagnosis ... Acquired Aplastic Anemia ... • Hypoplastic MDS ... #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... and Differential Diagnosis ... Acquired Aplastic Anemia ... • Hypoplastic MDS ... #Algorithm #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS ... #oncology #hematology ... #diagnosis #management
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Erythematosus - Diagnosis ... Manifestations: - Arthritis ... - Hemolytic anemia ... autoantibodies #signs ... #differential #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... platelets) • MDS ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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