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Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Deficiency • MDS ... Hypothyroid • Liver Disease ... #Macrocytic #Anemia ... #differential #diagnosis ... #algorithm #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Diagnosis: • Pancytopenia ... Treatment: • Consider ... Can progress to MDS ... #treatment #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia (sometimes ... , MDS, Chemotherapy ... autoimmune hemolytic anemia ... #differential #diagnosis ... #hematology #microscopy
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
, Hemolytic anemia ... : Hemoglobin H disease ... , Sickle cell, MDS ... Inclusions #Bodies #diagnosis ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia ... #Differential #Diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... Non-megaloblastic: Liver disease ... Reticulocytosis, MDS ... #Differential #Diagnosis ... #hematology
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Rheumatoid Arthritis ... Scleritis, Heart Disease ... Nodules, Pulmonary Disease ... #RA #diagnosis ... #rheumatology #signs
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... criteria for 1) hematologic ... • giant cell arteritis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... cytopenias (usually anemia ... only curative treatment ... Myelodysplastic #Syndrome #MDS ... #treatment #hematology
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
- Diagnosis Algorithm ... suspected: • Signs ... Iron-deficiency anemia ... unresponsive to treatment ... #Diagnosis #Algorithm
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