34 results
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Treatment: • Consider ... Can progress to MDS ... diagnosis #management #treatment
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS ... Treatment:
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... cytopenias (usually anemia ... only curative treatment ... Myelodysplastic #Syndrome #MDS ... Diagnosis #Management #treatment
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelets) • MDS ... precursors MDS ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Summary Clinical Signs ... hypercalcemia) • Anemia ... marrow plasma cells ... plus one of: • Anemia
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
yrs old; F>M Signs ... - Normocytic Anemia ... - Giant cells ... Pathophysiology #Diagnosis #Signs
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... myelodysplastic syndrome (MDS ... myelodysplastic syndrome (MDS ... hematopoietic stem cells ... blood myeloid cells
Suspected Celiac Disease - Diagnosis Algorithm

Celiac disease suspected:
 • Signs and symptoms of celiac disease
 •
suspected: • Signs ... Iron-deficiency anemia ... unresponsive to treatment ... discernable cause • Signs
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
lymphocytes, smudge cells ... 5) Symptoms of anemia ... transformation) Treatment ... marrow failure with anemia ... AIHA, PRCA) • Treatment
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
present, symptoms, signs ... Splenomegaly Treatment ... transformation into AML or MDS ... • Treatment is ... • Treatment algorithms