21 results
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Liver Disease, MDS ... myeloma Rouleaux: Chronic ... Multiple myeloma, Chronic ... differential #diagnosis #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Diagnosis Algorithm Signs ... • Extrinsic RBC ... • Intrinsic RBC ... Matthew Ho, MD ... Diagnosis #Algorithm #hematology
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Common RBC Inclusions ... , Hemolytic anemia ... , Sickle cell, MDS ... #RBC #Inclusions ... Bodies #diagnosis #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Illness Script Signs ... Treatment: • Consider ... Can progress to MDS ... diagnosis #management #treatment ... #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach to Anemia ... Spherocytosis, G6PD, PK, HbC ... Reticulocytosis, MDS ... Matthew Ho, MD ... Differential #Diagnosis #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS ... Pancytopenia: • ↓ RBC ... Treatment:
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Artifact (redo CBC ... : • Acute or Chronic ... effect following treatment ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... only curative treatment ... Myelodysplastic #Syndrome #MDS ... Diagnosis #Management #treatment ... #hematology #oncology
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
anorexia, ARDS ​• RBC ... severe hemolytic anemia ... coccobacillus within the RBCs ... TREATMENT: ​• Acute ... Gabriel Talledo MD
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
incidentally via CBC ... present, symptoms, signs ... transformation into AML or MDS ... • Treatment is ... #hematology