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differential dermatology management pancytopenia secondary systemic workup chronic classification generalized leukemia mds myelodysplastic neutropenia pruritus syndrome thrombocytosis alopecia approach cancer
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Expectation • Rx Algorithm ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... - Differential Diagnosis ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... #Algorithm #Causes
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Non-lmmune: • HELLP Syndrome ... #Algorithm #Causes ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Algorithm Decreased ... • Marrow Aplasia ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Algorithm Spurious ... effect following treatment ... Iron deficiency anemia ... #Algorithm #Causes
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... Deficiency • Aplastic ... #Algorithm #Causes ... #Hematology
Syncope - Differential Diagnosis Algorithm Neurocardiogenic: • Vasovagal • Orthostatic Hypotension • Autonomic Neuropathy • Situational (micturition,
- Differential Diagnosis ... Algorithm Neurocardiogenic ... Hypoglycemia • Anemia ... • AFib/AFlutter ... #Algorithm #causes
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Algorithm Consumption ... HLH syndrome 5. ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... #Algorithm #Hematology
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