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management oncology differential anticoagulation aplastic thrombocytosis causes chronic cll doac endoscopy esophageal leukemoid leukocytosis longterm lymphocytic malignancy mds myelodysplasia myelodysplastic
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
of hematologic ... B-symptoms, bruising/bleeding ... hepatomegaly • Labs: anemia ... #Algorithm #hematology ... #WBC #Leukemoid
Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
Treatment algorithm ... for VTE in Malignancy ... thrombosis in cancer ... #Cancer #Algorithm ... Anticoagulation #Management #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Algorithm Spurious ... Chronic Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
neutropenia • Mucosal bleeding ... Diagnosis: • Pancytopenia ... Treatment: • Consider ... to MDS or acute leukemia ... #treatment #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... #Algorithm #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
night sweats, bleeding ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... • Neutropenia, anemia ... microglobulin Treatment ... #diagnosis #workup ... #oncology #hematology
Esophageal Variceal Bleeding - Diagnosis and Management Summary PRE-ENDOSCOPY Vasoactive agents - Octreotide: • 50mcg bolus →
Esophageal Variceal Bleeding ... - Diagnosis and ... (if feasible): TTE ... #treatment #endoscopy ... #varices #hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... virus (EBV) • Leukemia ... Treatment: ... #oncology #hematology ... #diagnosis #management
Longterm Venous Thromboembolism Treatment Algorithm Treat for 3 months and reassess • Isolated distal DVT (without cancer)
Thromboembolism Treatment ... Algorithm Treat ... PE - High Bleeding ... therapy - Second VTE ... #hematology #anticoagulation
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