1952 results
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
glucose and amino acids ... reabsorption of organic acids ... including uric acid ... Segments #Function #Pathophysiology ... #Tubules #Table
Pathways Involved in Protein and Amino Acid Metabolism in Chronic Kidney Disease. The tricarboxylic acid (TCA)
Protein and Amino Acid ... tricarboxylic acid ... metabolize amino acids ... products of amino acid ... #Pathophysiology
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
to filter uric acid ... like lactic acid ... and keto-acids) ... secretion of uric acid ... Hyperuricemia #Pathophysiology
Gastric Acid Secretion - Pathophysiology
Chief cell - Pepsinogen
Parietal cell - Acid, Intrinsic factor
G cell - Gastrin
Inhibitors:
Gastric Acid Secretion ... - Pathophysiology ... Parietal cell - Acid ... Somatostatin Phases of acid ... #Secretion #Pathophysiology
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Action of Bile Acid ... Sequestrants Bile Acid ... ↓ Hepatic Bile Acid ... ↑ Hepatic Bile Acid ... sequestration #pathophysiology
Diuretics - summary table
Thiazides and Related Diuretics: HCTZ, Chlorthalidone, Metolazone, Indapamide, Bendroflumethiazide 
Loop Diuretics: Furosemide, Ethacrynic
Diuretics - summary table ... Furosemide, Ethacrynic acid ... #pharmacology #table
Tranexamic Acid: Mechanism of Action
 - TXA is an anti-fibrinolytic
 - TXA is a synthetic analog
Tranexamic Acid: ... analog of the amino acid ... #Tranexamic #Acid ... #pathophysiology
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Lactulose → ↑ Lactic Acid ... , Acetic Acid → ... ammonia #hepatology #pathophysiology
Therapeutic Advantages and Disadvantages of some NSAIDs
Salicylates: Aspirin, Salicylate salts, Diflunisal
Acetic acids: Indomethacin, Sulindac, Tolmetin
Propionic acids:
Diflunisal Acetic acids ... Tolmetin Propionic acids ... Fenamates: Mefenamic acid ... , Meclofenamic acid
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
syndrome (TLS) - Pathophysiology ... phosphate, and uric acid ... deposition of uric acid ... syndrome #TLS #Pathophysiology