109 results
Treatment of hyperkalemia via kaliuresis 
step 1 = volume resuscitation if hypovolemic
step 2 = consider fludrocortisone
step
fludrocortisone step 3 = diuretic ... determine response to diuretic ... #treatment #diuretics ... #diuresis #nephrology ... #algorithm
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... Thiazides-type diuretics ... Metolazone) 5) Potassium-sparing ... diuretics (e.g. ... #pharmacology #nephrology
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... empagliflozin LOOP DIURETICS ... DIURETICS • Spironolactone ... Triamterene OSMOTIC DIURETICS ... Tolvaptan #Diuretics
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
inhibitors, loop diuretics ... thiazide-like diuretics ... Postobstructive diuresis ... , Osmotic diuresis ... mimics thiazide diuretic
Diuresis in Critical Care - Achieving a Negative Fluid Balance
Advantages Of A Negative Fluid Balance:
 •
Diuresis in Critical ... Start with LOOP DIURETICS ... , address diuretic ... ) to normalize Potassium ... Balance #management #criticalcare
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Metolazone Loop diuretics ... Piretanide Potassium ... sparing diuretics
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Differential Diagnosis Algorithm ... >20 mEq/24 h - Diuretics ... Differential #Diagnosis #Algorithm ... #nephrology #causes ... #low #potassium
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... concentrating defect: • Diuretics ... • Osmotic diuresis ... Differential #Diagnosis #Causes ... #nephrology #sodium
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
the Nephron - Diuretics ... Acetazolamide 2) Osmotic Diuretics ... mannitol) 3) Loop Diuretics ... HCTZ) 5) Potassium-sparing ... #Nephron #Diuretics
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... Symport (Loop Diuretics ... ; High-Ceiling Diuretics ... Symport - Thiazide Diuretics ... Kidney stones caused