17 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Anti-cardiolipin (aCl ... LAC) • Sjogren Syndrome ... #diagnosis #associations
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... Induction Rx: high-dose ... #CNS #neurology ... #rheumatology #
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
lupus cases, drug-dependent ... thiazidic, PPI, ACE ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... least 2 joints • Neurologic ... Classification #Criteria #SLE ... Erythematosus #diagnosis ... #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... complements and a high ... erythematosus (ACLE ... Differential Diagnosis ... #Rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... psychiatric changes), high ... #hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... in drug-induced SLE ... • Sjögren syndrome ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... WBC count cause ... have fever - ACS ... Spontaneous if high ... #TLS #diagnosis
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• NSAIDs • ACE ... - Tumor lysis syndrome ... insufficiency/Failure • SLE ... #causes #potassium ... #high #nephrology
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
TMAs cause MAHA ... Cr>2.3 & platelets ... catastrophic APS, SRC, SLE ... There is a high ... #diagnosis #ttp