10 results
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia
Induction: 
 • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate
Consolidation
Cytarabine #ALL ... Treatment #timeline #oncology ... #pediatrics #peds ... #management
Naloxone for Clonidine Overdose
Indication: Altered mental status, CNS depression or respiratory depression due to clonidine overdose
Dosing:
Pediatrics: 10 mg ... IV push all at ... strongly supported in pediatric ... Clonidine #Overdose #toxicology ... #management
Naloxone - Toxicology

Adult starting dose:
 - 0.4 mg IV/IM/IO/SQ for non-opioid dependent patients
 - 0.04 mg
Naloxone - Toxicology ... opioid-dependent patients Pediatric ... Naloxone #Narcan #Toxicology ... #Management #Pharmacology
Baclofen Toxicology

 • Baclofen is an agonist at GABA-B receptors, similar to GHB. Benzodiazepines, Barbiturates, Ethanol,
Baclofen Toxicology ... and Propofol are all ... #Baclofen #Toxicology ... #pharmacology # ... diagnosis #management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... Immunohistochemical studies (to differentiate ... classification #hematology #oncology ... #management
Hypotension - Guidelines for Crises in Anaesthesia

Hypotension is commonly due to unnecessarily deep anaesthesia, the autonomic
reservoir bag and APL ... adult, 10 ml.kg-1 paediatric ... #Hypotension #Differential ... Checklist #Diagnosis #Management
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... be effective in all ... Leucovorin #Antidote #Toxicology ... #Toxicity #Management ... #Pharmacology
Differential Diagnosis: New-Onset Seizure in the Elderly

STRUCTURAL:
 • Stroke/TIA, Subdural hematoma, mass
 • Traumatic Brain Injury
Differential Diagnosis ... seizure threshold TOXICOLOGIC ... Patients with all ... #Differential #Diagnosis ... Elderly #Neurology #Geriatrics
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity
Anthracyclines cause cardiomyopathy:
 ✖ Reduction in left ventricular ejection fraction
Management of Anthracyclines ... after 4 cycles for all ... Cardiotoxicity #cardiology #oncology ... #pharmacology #