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diagnosis management differential hematology algorithm guidelines lupus sle systemic acr2021 classification erythematosus oncology syndrome syndromes table causes cryoglobulinemia pulmonary renal
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... Vasculitis: • ... 90% • Anti-GBM disease ... antibodies #diagnosis #rheumatology ... #diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... c-ANCA - Vasculitis ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
Vasculitis A group ... , small-vessel vasculitis ... - C-ANCA pattern ... PR3 Anti-GBM disease ... PR3 #Diagnosis #Rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
- Kawasaki disease ... small vessels - ANCA-associated ... and infectious diseases ... - serum disease ... Vessels #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... well as inner ear disease ... atherosclerotic disease ... most important diseases
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... Nodosa (PAN), ANCA ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... Differential #Diagnosis #rheumatology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
glomerulonephritis 90%: - ANCA ... - Anti-GBM Disease ... Double Positive (ANCA ... , Behcet's Disease ... , mitral valve disease
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (MPA) - ANCA ... Vasculitis Management ... Algorithm - ACR ... #Treatment #ACR2021 ... Guidelines #algorithm #rheumatology
Polyarteritis Nodosa (PAN) - Vasculitis Management Algorithm - ACR/VF 2021 Guidelines • Severe Disease → Remission
Management Algorithm - ACR ... Guidelines • Severe Disease ... • Non-Severe Disease ... #Management #Treatment ... Guidelines #algorithm #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
involvement: Anti-GBM Disease ... (C-ANCA): GPA > ... (P-ANCA): eGPA, ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
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