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diagnosis differential management lupus antibodies classification dermatology diseases druginduced erythematosus hematology pulmonary systemic table thrombocytopenia algorithm ana antibody antineutrophil antinuclear
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
in drug-induced SLE ... scleroderma) - Anti-Scl ... Vasculitis: • ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group < 5%
, causes and management ... - French Vasculitis ... neuropathy Treatment ... with refractory disease ... #Vasculitis #Rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
syndrome Anti-Scl ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... - Vasculitis, e.g ... diagnosis #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... +MPO) • Cryoglobulinemic ... Low levels mixed cryoglobulinemia ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Lupus Nephritis, Cryoglobulinemia ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
glomerulonephritis 90%: - ANCA ... Double Positive (ANCA ... Complement Levels: SLE ... , Cryoglobulinemic ... differentiation syndrome in APL
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... /HSP • Cryoglobulinemia ... (MIXED) • ANCA ... Associated - SLE ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... : - 10% SLE or ... DDX: • ANCA (Antineutrophil ... classification #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... Urticarial/LCV) - Cryoglobulinemic ... ANCA Associated: ... : • Behcet Disease ... #dermatology #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... Nodosa (PAN), ANCA ... associated vasculitis ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
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