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differential management autoantibodies lupus comparison erythematosus systemic ana antinuclear associations causes chronic cll lymphocytic signs thrombocytopenia workup algorithm anemia aplastic
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... Leukemia, Tumour ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... Algorithm #Causes #Hematology
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific Antibodies ... TIF1y, NXP2, Mi-2, SAE ... MSAs #clinical #diagnosis ... #rheumatology # ... table
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... ) CLL Symptoms: ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Most common leukemia ... minimal tumor burden Diagnosis ... 3) Monoclonal antibodies ... #oncology #hematology ... #hemeonc #diagnosis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... others (RNP, aPL antibodies ... Autoantibodies #Rheumatology ... #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Associations #diseases #diagnosis ... #table #rheumatology ... #antibodies
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
RA, SLE), Post-partum ... promyelocytic leukemia ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... with no early symptoms ... phenomenon CLL Diagnosis ... #diagnosis #workup ... #oncology #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
involvement 3% SLE-Related ... Auto-Antibodies ... Lupusreference #SLE ... autoantibodies #signs #symptoms ... #differential #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Highly specific for SLE ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
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