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hematology differential anemia causes deficiency extravascular iron workup agglutinin cold disease enlarged fe ferritin macrocytic microcytic normocytic spleen splenomegaly testing
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... Hemolysis: • Mechanical ... Hemolysis: • ... lymphoproliferative disorders ... #Hemolytic #Intravascular
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... Diagnosis Algorithm ... and RES-mediated hemolysis ... - Hemolysis within ... immune-complex hemolytic
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Algorithm Labs ... • Iron loss: Intravascular ... ) hemolysis, Intensive ... intake: Anorexia, Pregnancy ... #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Algorithm Decreased ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... Hypothyroid • Pregnancy ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... Consider RBC membrane disorder ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... the RBCs causing intravascular ... hemolysis on rewarming ... agglutinin #disease #hemolytic
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential Diagnosis ... Algorithm Infectious ... Myeloproliferative disorders ... Serum Sickness Hemolytic ... #Hematology
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
- Differential Diagnosis ... Algorithm • Blood ... • Iron loss: Intravascular ... hemolysis, (PNH ... , Adolescence, Pregnancy
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... acute blood loss, hemolysis ... (BM) ablative disorders ... #Diagnosis #Workup ... #Hematology #Microcytic
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