128 results
Diagnosis Adrenal Insufficiency - Algorithm

Step 1) Screening Test: 6-8AM Cortisol Level
 - Early morning cortisol levels
specificity for AI ... > 15 excludes AI ... - Check ACTH ... have diagnosed AI ... primary vs secondary AI
Adrenal Insufficiency Diagnosis Algorithm - Evaluation of HPA Axis Response to ACTH

Early am cortisol < 3
Axis Response to ACTH ... primary OR secondary AI ... Measure ACTH: ... High = primary AI ... Diagnosis #Algorithm #ACTH
Algorithm for the diagnosis of adrenal insufficiency (AI). The standard cosyntropin stimulation test (CST) may be
insufficiency (AI ... secondary or tertiary AI ... ACTH, adrenocorticotropic ... Diagnosis #Endo #ACTH
Primary vs Secondary Adrenal Insufficiency - Pathophysiology
Primary AI = adrenal glands themselves are the problem. This
Pathophysiology Primary AI ... be low, while ACTH ... Secondary AI = the ... Low ACTH leads to
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm
ACTH-Dependent (Secondary):
 • Pituitary Dysfunction
 • Hypothalamic Dysfunction
ACTH-Independent (Primary):
Diagnosis Algorithm ACTH-Dependent ... Hypothalamic Dysfunction ACTH-Independent ... Insufficiency #AI
Adrenal Insufficiency - Diagnosis and Management Summary
Primary Adrenal Insufficiency:
Most Common Cause in the US: Autoimmune Adrenalitis
Other
In secondary AI ... is absent (low ACTH ... diagnostic of AI ... ACTH STIM TEST: ... baseline cortisol and ACTH
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
AM cortisol and ACTH ... /dL -> Primary AI ... present - ACTH ... ug/dL Primary AI ... present - ACTH
Adrenal Crisis
Do not confuse acute adrenal crisis with Addison disease. In 1855, Thomas Addison described a
hydrocortisonr #ACTH ... #AI ##adrenals
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
, RTA Type IV, AI ... levels, Cortisol+ACTH
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm
Exogenous (ACTH-independent)
Endogenous
 • ACTH-dependent:
    - ACTH-secreting
Algorithm Exogenous (ACTH-independent ... Endogenous • ACTH-dependent ... : - ACTH-secreting ... Disease) - ACTH-secreting ... in the body • ACTH-independent