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Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... 2) LOOK FOR a cause ... screening 3) TREAT AIHA ... Warm #Antibody #Autoimmune
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... (AIHA) "Warm" ( ... idiopathic) - Autoimmune ... (AIHA)"Cold" (usually ... Extravascular #Causes
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Atypical HUS, autoimmune ... atheroembolic, AIHA
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Ischemia • Autoimmune ... • Drugs • AIH ... Diagnosis #Algorithm #Causes
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Table Warm AIHA ... MatthewHoMD #Autoimmune ... Hemolytic #Anemia #AIHA
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Anemia (AIHA) ... Non-Hodgkin Lymphoma Autoimmune ... NikitaSonaliyaD #Autoimmune ... Hemolytic #Anemia #AIHA
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... - Warm vs Cold AIHA ... Warm AIHA: - 70% ... spherocytes Cold AIHA ... #Autoimmune #Hemolytic
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • Cold AIHA ... • Alloimmune ... • Drug-induced AIHA ... Diagnosis #Algorithm #Causes
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... Warm AIHA: 1) Steroids ... #Autoimmune #Hemolytic ... #Anemia #AIHA #
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolysis: • Autoimmune ... Hemolytic Anemias (AIHAs ... ) • Alloimmune
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