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Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Hemolytic Anemia (AIHA ... - Differential Diagnosis ... Table Warm AIHA ... DAT-negative AIHA ... #Differential #Diagnosis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Hemolytic Anemia (AIHA ... - Warm vs Cold AIHA ... Warm AIHA: - 70% ... spherocytes Cold AIHA ... Pathophysiology #diagnosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... #Differential #Diagnosis
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Hemolytic Anemia (AIHA ... ) WARM AHA - ... alpha-methyldopa COLD AHA ... Hemolytic #Anemia #AIHA ... #Diagnosis #Differential
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia 1) DIAGNOSE ... AIHA • Anemia ... screening 3) TREAT AIHA ... Hemolytic #Anemia #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Autoimmune: Warm AIHA ... , Cold AIHA, Transfusion ... #Differential #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... - Autoimmune (AIHA ... - Autoimmune (AIHA ... #differential #diagnosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
- Differential Diagnosis ... Viral, Ischemia, AIH ... - Viral, AIH ... Alcohol, Viral, HH, AIH ... Transaminitis #Algorithm #diagnosis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
atheroembolic, AIHA ... CHAMPS #Mnemonic #diagnosis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Hypersplenism • AIHA ... #Differential #Diagnosis
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