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Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Hemolytic Anemia (AIHA ... ) - Differential ... Table Warm AIHA ... DAT-negative AIHA ... #Differential #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis - Differential ... Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... Extravascular #Differential
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Hemolytic Anemia (AIHA ... ) WARM AHA - ... alpha-methyldopa COLD AHA ... Hemolytic #Anemia #AIHA ... #Diagnosis #Differential
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
1) DIAGNOSE AIHA ... • Blood smear: Differential ... screening 3) TREAT AIHA
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA ... , Cold AIHA, Transfusion ... #Hemolysis #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
- Autoimmune (AIHA ... - Autoimmune (AIHA ... Extravascular #Causes #differential
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
atheroembolic, AIHA ... Mnemonic #diagnosis #differential
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Hypersplenism • AIHA ... Hemolytic #Anemia #Differential
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias - Differential ... Hemolytic Anemias (AIHAs ... Hemolytic #Anemias #Differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Viral, Ischemia, AIH ... - Viral, AIH ... Alcohol, Viral, HH, AIH
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