41 results
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
limb Gitelman syndrome ... cell epithelial sodium ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential Diagnosis ... Osmolarity 3) Urine Sodium ... Uric Acid → renal salt ... #Algorithm #nephrology ... #sodium #low #uricacid
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
in cardiorenal syndrome ... hypertrophy • Sodium ... release • ↓ Cl ... #cardiorenal #syndrome ... pathophysiology #nephrology
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
Cirrhosis, Nephrotic syndrome ... osmostat, Cerebral salt ... Hyponatremia #Algorithm #diagnosis ... #sodium #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... autosomal recessive salt-losing ... thiazide-sensitive sodium-chloride ... Pathophysiology #nephrology ... #diagnosis
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Hypervolemic (Excess salt ... , Cushing syndrome ... Workup #Algorithm #nephrology ... #sodium
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
- Differential Diagnosis ... insipidus Excessive salt ... #Differential #Diagnosis ... #Causes #nephrology ... #sodium #high
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
losses, Cerebral salt ... Cirrhosis, Nephrotic syndrome ... Hyponatremia #algorithm #diagnosis ... #sodium #low #nephrology
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Cerebral Salt Wasting ... Neurological event 2) Sodium ... Pathophysiology #diagnosis ... #nephrology #hyponatremia
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
- Differential Diagnosis ... , Gitelman Syndrome ... , Liddle syndrome ... #Differential #Diagnosis ... #Algorithm #nephrology