3100 results
Recurrent / Breakthrough DVT During Anticoagulation

Subtherapeutic Anticoagulation
Hypercoagulable State 
 - Antithrombin deficiency 
 - Hypercoagulability ot
Behcet's disease - APLS ... - May-Thurner syndrome ... anticoagulation #hematology #differential
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... hemolytic-uremic syndrome ... anemia" • HELLP syndrome ... • Catastrophic APLS ... #schistocytes #differential
Raynaud Phenomenon Differential Diagnosis:

Rheumatologic

 - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD
Heme

 -
Raynaud Phenomenon Differential ... , SLE, Sjogren syndrome ... Antisynthetase syndrome ... Hypercoagulable state (eg APLA ... #Differential
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal Syndromes ... and Mimics - Differential ... Antiphospholipid Syndrome ... in APL - Cardiac ... #Mimics #Differential
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Thrombocytopenia - Differential ... SLE • CLL • APLA ... Non-lmmune: • HELLP Syndrome ... Thrombocytopenia #Differential
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... initiation • Differential ... unless severe APLS ... Differentiation #Syndrome
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Arterial Thrombosis - Differential ... Hyperviscosity, TTP, APLS ... • Nephrotic Syndrome ... Antiphospholipid antibodies (APLS ... pathophysiology #hematology #differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Kasabach-Merritt syndrome ... - PNH - APLS ... Gardner-Diamond syndrome ... Vasculopathy #Purpura #Differential
St. VITUS'S DANCE Mnemonic for Causes of Chorea

S - Sydenham’s Chorea
V - Vascular (Strokes)
I - Increased
stimulants) A - APLA ... syndrome N - Neurodegenerative ... Mnemonic #Chorea #Differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Shrinking lung syndrome ... Antiribosomal P, APLA ... disorders • CAD APLA ... valve vegetations APLA