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diagnosis algorithm causes hemolytic cardiology hemolysis rheumatology systemic agglutinin atlas bandemia bloodcell cbc classification disease erythematosus extravascular framework infectiousdiseases intravascular
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • AIHA: warm, cold ... AS, prosthetic valve ... classification #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... mechanical cardiac valve ... bartonella (oroya fever ... Algorithm #workup #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis - Differential ... Warm AIHA • Cold ... immune-complex hemolytic anemia ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Mechanical valve ... Cell Agglutinate: Cold ... , Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... quinine, etc) - Viral ... - Mechanical: valve ... replacement, endocarditis ... Diagnosis #Framework #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Autoimmune: Warm AIHA, Cold ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Diseases Nail Fold ... Iron deficiency anemia ... • Bacterial endocarditis ... Systemic #Secondary #dermatology ... #Differential #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... Symptoms: High fevers ... #hematology #diagnosis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... mountain spotted fever ... • Bacterial endocarditis ... #Diagnosis #hematology ... #nonpalpable #dermatology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Involves aortic and mitral ... night sweats, fever ... Marantic (NTBE) Differential ... Leukocytosis, anemia ... Persistent bacteremia/fevers
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