19 results
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Agglutination - Cold ... mechanical cardiac valve ... bartonella (oroya fever ... Algorithm #workup #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... mountain spotted fever ... • Bacterial endocarditis ... #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... quinine, etc) - Viral ... - Mechanical: valve ... replacement, endocarditis ... Diagnosis #Framework #hematology
Fever and Rash - Differential Diagnosis Framework
 • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... Differential Diagnosis ... Framework • Viral ... gonorrhea, Rickettsial diseases ... #Diagnosis #dermatology
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Involves aortic and mitral ... night sweats, fever ... Marantic (NTBE) Differential ... Paradoxical emboli via ASD ... Persistent bacteremia/fevers
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Autoimmune: Warm AIHA, Cold ... , Drugs, Liver Disease ... #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... Causes: • Liver disease ... • AIHA: warm, cold ... AS, prosthetic valve ... classification #hematology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Subacute bacterial endocarditis ... Cardiovascular system • Mitral ... - Bacterial endocarditis ... #joint #pain #differential ... #diagnosis #rheumatology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Nail Fold Abnormality ... • Bacterial endocarditis ... Systemic #Secondary #dermatology ... #Differential #
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Anemia, Mechanical valve ... Cell Agglutinate: Cold ... anemia, Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology