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diagnosis rheumatology cardiology erythematosus lupus pain arthritis msk systemic approach causes clues conditions dermatology extrarticular framework infectiousdiseases management monoarthritis monoarticular
Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective
inflammation (SLE ... • Prosthetic valve ... annulus valve: ... cardiomyopathy - VA Joint ... Regurgitation #differential
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint ... Subacute bacterial endocarditis ... - Bacterial endocarditis ... #pain #differential ... #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... ) General: Fever ... phenomenon (20%) Joints ... Pericarditis, Endocarditis ... , Aortic valve lesions
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
quinine, etc) - Viral ... - Autoimmune: SLE ... - Mechanical: valve ... replacement, endocarditis ... Diagnosis #Framework #hematology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
acute rheumatic fever ... • Acute = Viral ... Chronic = RA, SLE ... #rheumatology # ... approach #workup #differential
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Involves aortic and mitral ... • Autoimmune (SLE ... night sweats, fever ... Marantic (NTBE) Differential ... Persistent bacteremia/fevers
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... • Rheumatic fever ... • Bacterial endocarditis ... arthritis • SLE ... #pain #Differential
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Splenomegaly - CTD (SLE ... Associated - SLE ... mountain spotted fever ... • Bacterial endocarditis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... Arthritis: • Joint ... • Libman-Sacks endocarditis ... Cytopenias • Cardiac valve
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
) Inflammatory joint ... the face (many differential ... ; sometimes « viral ... 9) Unexplained fever ... lupus #diagnosis #sle
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