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cardiology erythematosus hematology lupus pain sle arthritis causes msk primary regurgitation systemic workup algorithm anemia approach clues comparison conditions dermatology
Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective
• Prosthetic valve ... annulus valve: ... cardiomyopathy - VA Joint ... Regurgitation #differential ... #diagnosis #cardiology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Subacute bacterial endocarditis ... Cardiovascular system • Mitral ... - Bacterial endocarditis ... #pain #differential ... #diagnosis #rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... acute rheumatic fever ... • Acute = Viral ... #rheumatology # ... approach #workup #differential
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: Fever ... Pericarditis, Endocarditis ... , Aortic valve lesions ... signs #symptoms #diagnosis ... #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Diagnosis Framework ... quinine, etc) - Viral ... - Mechanical: valve ... replacement, endocarditis ... #hematology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Involves aortic and mitral ... night sweats, fever ... Marantic (NTBE) Differential ... Persistent bacteremia/fevers ... #Endocarditis #diagnosis
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
, Fever, No muscle ... Detectable HIV viral ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... Diagnosis Framework ... • Bacterial endocarditis ... #Diagnosis #MSK ... #rheumatology #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... genotypes): SS, SC ... mechanical cardiac valve ... bartonella (oroya fever ... #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... mountain spotted fever ... • Bacterial endocarditis ... #Diagnosis #hematology ... #rheumatology #
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