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Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Weakness - Dark urine ... Hyperuricemia • Hyponatremia ... + myoglobin AKI ... hour with goal urine ... hyperkalemia or ATN
Urine Electrolyte Interpretation - AKI, Hyponatremia, Hypokalemia and Non-Gap Metabolic Acidosis

#Urine #Electrolytes #Interpretation #ULytes #AKI #FENa
Urine Electrolyte ... Interpretation - AKI ... , Hyponatremia, ... Metabolic Acidosis #Urine ... Interpretation #ULytes #AKI
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
UOP/weights - Urine ... protein/Cr - Renal ... Liano 1996) - ATN ... CKD— 13% (mostly ATN ... and pre-renal)
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
Approach to Hypotonic Hyponatremia ... volume-based algorithm Urine ... ≥100): SIADH, Renal ... deficiency, Post-AKI ... Losses (AKI, Post-AKI
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... GI losses • Renal ... • Reduced GFR, AKI ... Hypo-osmolar urine ... osmole intake #Hyponatremia
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... GI losses • Renal ... • Reduced GFR, AKI ... Hypo-osmolar urine ... osmole intake #Hyponatremia
General approach to AKI - Checklist

Urine electrolytes & FENa - Previously, it was believed that urine
General approach to AKI ... - Checklist Urine ... differentiate between pre-renal ... and intrinsic renal ... @PulmCrit #AKI
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Based Approach to Hyponatremia ... Na <20: Extra-renal ... Na >30: Renal losses ... Na > 30: Renal ... SatyaPatelMD #Volume #Hyponatremia
Causes of Acute Kidney Injury - Differential Diagnosis Framework 
Pre-Renal
Post-Renal
Intrinsic Renal:
 • Tubules (ATN)
 • Glomerular:
Framework Pre-Renal ... Post-Renal Intrinsic ... Renal: • Tubules ... (ATN) • Glomerular ... drtonydang @CMC_IM #AKI
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Kidney Injury (AKI ... gammopathy of renal ... malignancies Treatment ... Cisplatin • ATN ... Kidney #Injury #AKI