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hematology differential causes algorithm management allergy blood hemolysis hemolytic hypersensitivity product types allergic approach arthritis comparison conjugated definitions dermatology erythematosus
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Autoimmune Hemolytic anemia ... Target: Antigen-Ab ... Dermatitis (ie. reaction ... #Types #Classification ... #Diagnosis #Definitions
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
hypersensitivity reactions ... Days (Hemolytic Anemia ... hypersensitivity #reactions ... #Types #Classification ... #Allergy #Diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... hemolysis, deficiency anemia ... Inflammatory Conditions: Rheumatologic ... syndrome, POEMS • Reaction ... #Differential #Diagnosis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Transfusion reactions ... #causes #classification ... #hematology
Rheumatoid Arthritis - 2020 ACR-EULAR Classification ≥ 6 of 10 points = definite RA Joint Involvement:
2020 ACR-EULAR Classification ... negative anti CCP Ab ... Rheumatoid #Arthritis #diagnosis ... #EULAR #Classification ... #rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... - Differential Diagnosis ... #MCV #Classification ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... - Differential Diagnosis ... #Classification ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... Other: Transfusion reaction ... #differential #diagnosis ... #hematology #anemia
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... AIHA, Transfusion reactions ... Defects: Sickle cell anemia ... #Differential #Diagnosis ... #hematology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of ... (eg, hemolytic anemias ... , hemolytic reactions ... syndrome, drug reactions ... #diagnosis #conjugated
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