145 results
Pharmacology of diuretics

Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride

Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Bioavailability, Absorption ... Pharmacology #Comparison #Table ... #HalfLife #Dosing
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
Phosphate binders ... CKD will require phosphate ... since they are not able ... based on serum phosphate ... Hyperphosphatemia #Dose #Dosing
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
heparin Acute Phosphate ... Exogenous: Excessive phosphate ... intake, Phosphate ... Increased Renal Phosphate ... Absorption:
Hydroxychloroquine and Chloroquine in COVID19

Dosing:
Hydroxychloroquine:
 - 400mg PO BID on the first day, followed by 200mg
in COVID19 Dosing ... if concerns for absorption ... 500mg Chloroquine phosphate
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
Commonly Used Phosphate ... - No systemic absorption ... - Significant absorption ... amzn.to/34t5DgJ #Phosphate ... #Binders #Table
Total-Body Deficits in Chronic Alcohol-Use Disorder. Patients with chronic alcohol-use disorder may have total-body deficits of
total-body deficits of phosphate ... magnesium, and calcium owing ... gastrointestinal absorption
Hypophosphatemia - Differential Diagnosis Algorithm
 • Decreased intake/absorption: Starvation, Alcoholism, Malabsorption, Phosphate binder use
 • Redistribution/
Decreased intake/absorption ... Malabsorption, Phosphate ... causes #nephrology #phosphate
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
Increased Intake / Absorption ... Hypervitaminosis D • Phosphate ... Supplementation • Phosphate
Hypophosphatemia - Differential Diagnosis Algorithm
Appropriately Low Kidney Phosphate Excretion:
 • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Appropriately Low Kidney Phosphate ... • Decreased GI Absorption ... Diarrhea, Antacids, Phosphate ... Inappropriately High Kidney Phosphate
Phosphate Binders - Pros and Cons

Calcium carbonate (TumsTM) 
 - Most inexpensive, antacid properties useful for
Phosphate Binders ... less GI calcium absorption ... amzn.to/34t5DgJ #Phosphate ... #Binders #Table