385 results
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
staining (lg + complement ... MGPN • Complement ... of alternative complement ... (Dense deposit disease ... MPGN without complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Vasculitis - Anti-GBM Disease ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement ... Vasculitis, Behcet's Disease ... , mitral valve disease
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
Effect of Selected Diseases ... on Complement Levels ... ThePeanutKidney #Complement
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
meningococcal disease ... is rare Normal complement ... response: The complement ... activation -> Complement ... C7, C8, C9 -> Complement
Lyme Disease: Early and Late Clinical manifestations
Stage 1. Localized
 • EM appears 7-14 days at the
Lyme Disease: Early ... joints - Remitting ... WuidQ #Lyme #Disease
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... 80% - Low complement ... Usual therapeutic management ... Evolution: Chronic disease ... Erythematosus #Diagnosis #Management
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Chain deposition disease ... Hypocomplementemia #Low #Complement
Admitting in the ICU - Checklist
VITALS: If bad, stop and go see the patient immediately; you
Admitting in the ... esp in work-up/management ... @EmmGeezee #Admitting
Excellent overview of the emergency department approach to atraumatic sudden onset headaches- including proposed algorithm and
considerations for omitting ... SuddenOnset #Diagnosis #Management