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treatment lupus oncology sle symptoms systemic differential erythematosus blood causes chronic cll hemeonc hemophagocytic hlh leukemia lymphocytic lymphohistiocytosis product reactions
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... PT, aPTT(liver disease ... #Causes #Workup ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Schistocytes, thrombocytopenia ... #Differential #Diagnosis ... #Algorithm #workup ... #hematology #testing
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Neurological 12% - Thrombocytopenia ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
pain (20%) Renal disease ... Leucopenia/lymphopenia, Thrombocytopenia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation C Congestive Heart Failure 1 H Hypertension 1 A2 Age >75 2 D Diabetes Mellitus 1 S2 Stroke,
2 V Vascular disease ... CHADS2VASc #HASBLED #Comparison ... Anticoagulation #AFib ... #Diagnosis #Hematology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune disease ... skin thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... • Immunologic Workup ... Evolution: Chronic disease ... Erythematosus #Diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
highly inflammatory disease ... leukopenia, anemia, and thrombocytopenia ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
late adulthood • Diagnosis ... specifically immune thrombocytopenia ... and M panel Management ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
transfusion • Thrombocytopenia ... • Severe Liver Disease ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
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