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ana antibody antinuclear erythematosus lupus patterns testing autoantibodies chronic cll clues cytoplasmic differentiation leukemia lymphocytic management mds mimickers myelodysplasia myelodysplastic
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antibody Testing - Nuclear ... pattern: - SLE ... conditions - Sp-100, PML ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... involvement 3% SLE-Related ... ) 30-45% Differential ... Lupusreference #SLE ... #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Triggers: ATRA treatment ... initiation • Differential ... Renal Failure Treatment ... #hematology #oncology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... the face (many differential ... diagnoses, including ... search ANA and aPL ... erythematosus #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Homogeneous pattern: • SLE ... pattern: • SjS, SLE ... conditions • Sp-100, PML ... #Patterns #differential ... #diagnosis #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... phenomenon CLL Diagnosis ... microglobulin Treatment ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... blood count with differential ... marrow studies Treatment ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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