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Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
bind to harmless allergens ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen ... conjunctivitis • Anaphylaxis
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... exposure to a likely allergen ... exposure to known allergen ... Angioedema #Anaphylaxis
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... Local and systemic anaphylaxis ... hay fever, food allergies ... , and drug allergies
Anaphylaxis Diagnostic Criteria Anaphylaxis is highly likely when any one of the following 2 criteria are fulfilled: 1.
Anaphylaxis Diagnostic ... Criteria Anaphylaxis ... exposure to non-food allergens ... highly probable allergen ... #Anaphylaxis #diagnosis
Triggers of Anaphylaxis Anaphylaxis is a systemic response to a specific allergen, usually occurring within one hour
Triggers of Anaphylaxis ... Anaphylaxis is ... to a specific allergen ... Diagnosis #Allergy #Anaphylaxis
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 Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... hours - Examples: Anaphylaxis ... Hay fever, Food allergies ... , Drug allergies
Stepwise approach for managing asthma in youths greater than 12 years of age and adults as
Allergen immunotherapy ... those with single allergies ... identify and treat anaphylaxis
Causes of Urticaria Immunoglobulin E (IgE) mediated - Aeroallergens - Contact allergen - Food allergens - Insect
Aeroallergens - Contact allergen ... - Food allergens ... mediated - Contact allergen
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 Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... cephalosporin), Food allergies ... Immunological Target: Allergen
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Initial exposure to allergen ... recognize antigen on allergen's
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