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Amphotericin B - Pharmacology Summary Sheet

Class: Polyene Antifungal
Mechanism of Action:
 • Binds to ergosterol → Complexes
Amphotericin B - ... Pharmacology Summary ... Formulations: Amphotericin ... #AmphotericinB ... #Pharmacology #ambisome
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview

Mechanism: binds ergosterol in membrane and
Antifungal Polyenes - Amphoterecin ... #Pharmacology #Antibiotics ... Polyenes #Antifungal #AmphoterecinB
Antifungal Agents Frequently Used in Leukemia
Antibiogram:
 • Fluconazole
 • Itraconazole
 • Voriconazole
 • Posaconazole
 • Caspofungin
Anidulafungin • Amphotericin ... #antibiogram #pharmacology
IDSA Recommendations for Treating Visceral and Cutaneous Leishmaniasis in HIV-AIDS
Treating Visceral Leishmaniasis - Preferred Therapy:
 •
• Liposomal amphotericin ... • Liposomal amphotericin ... • Liposomal amphotericin ... 4 weeks or • Amphotericin ... infections #HIVAIDS #pharmacology
Drugs that Cause Fever
Most commonly:
Amphotericin B, Antihistamines, Asparaginase, Barbiturates, Bleomycin sulfate, Methyldopa, Penicillins, Phenytoin sodium, Procainamide,
Most commonly: Amphotericin ... differential #diagnosis #pharmacology
Classification of Some Antimicrobial Agents by Their Sites of Action
Inhibitors of metabolism: Sulfonamides, Trimethoprim
Inhibitors of cell
function: Isoniazid, Amphotericin ... sites #action #pharmacology
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
flucytosine; AMB, amphotericin ... antibiogram #management #pharmacology
Antifungal Coverage Activity Antibiogram 

Spectrum of action of systemic antifungal agents. Solid blocks represent species in
AMB = amphotericin ... Echinocandins #Pharmacology
Drugs Implicated in Hemolytic Anemia
 • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
binds to RBC): Amphotericin ... differential #diagnosis #pharmacology
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
combination with Amphoterecin ... #Pharmacology #Antibiotics