27 results
diagnosis causes algorithm classification management workup chronic cold monoclonal rheumatology thrombocytosis acute agglutinin aki arteritis atlas autoimmune bloodcell calculation cll
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Hemolytic Anemia ... Lymphoproliferative disorder ... , Autoimmune disorder ... #Anemia #hematology ... #diagnosis #comparison
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Bleed • Hemolysis ... Inflammation • Cancer ... #Differential # ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider RBC membrane disorder ... #Anemia #Differential ... Algorithm #workup #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... Unstable hemoglobin disorders ... Cold autoimmune hemolytic ... RBC #Morphology #differential ... #diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g. cancer ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Production #Index #hematology ... #anemia #differential
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... telomeropathy Cancer ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... Diagnosis #Causes #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... • Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... blood loss, Acute hemolysis ... , deficiency anemia ... Malignancy: Metastatic cancer ... Thrombocytosis #Platelets #Differential
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