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diagnosis differential causes hematology algorithm anemia management nephrology workup nutrition classification pathophysiology rheumatology clinical signs symptoms testing laboratory table dermatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Thalassemia, Iron ... deficiency anemia ... Microangiopathic Hemolytic ... elliptocytosis, Severe iron ... deficiency anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
• Microcytic - Iron-deficiency ... , Liver diseases ... spherocytosis, Hemolytic ... , Thalassemia, Iron-deficiency ... Schistocytes - Hemolytic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
inflammation) • Iron ... deficiency • ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Non-megaloblastic: Liver disease
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... Anemia - Differential ... extravascular) hemolysis ... Structural: Celiac disease ... #Deficiency #Anemia
Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing SUMMARY: - RDW, FEP, serum iron,
Iron Deficiency ... Anemia vs Anemia ... of Chronic Disease ... #Deficiency #Anemia ... #Chronic #Disease
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (<80 fL) • Iron ... Deficiency • ... • Bleeding • Hemolysis ... 100 fL) • B12 Deficiency ... • Folate Deficiency
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... • Early Iron ... Deficiency #
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... → Sickle Cell anemia ... malignancy, autoimmune disease ... anemia (TTP, HUS
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Deficiency Anemia ... patients with anemia ... deficiency if: ... Test for celiac disease ... #Deficiency #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell disease ... , Hemoglobin H disease ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential
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