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diagnosis differential hematology algorithm anemia management nephrology classification rheumatology workup nutrition dermatology iron sle erythematosus systemic glomerular hyperkalemia oncology reactions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... usually IgG) (e.g. lupus ... G6PD deficiency) ... Extravascular #Causes
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... → Sickle Cell anemia ... malignancy, autoimmune disease ... Diagnosis #Algorithm #causes
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC: Pyridoxine deficiency ... disease anemia ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... 80 fL) • Iron Deficiency ... • Bleeding • Hemolysis ... • Folate Deficiency ... Diagnosis #Algorithm #Causes
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... , Hemoglobin H disease ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... • Early Iron Deficiency ... Diagnosis #Algorithm #Causes
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Defects • G6PD deficiency ... • PK deficiency ... anemia • ... Diagnosis #Algorithm #Causes
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... : • GATA2 deficiency ... • Fanconi’s anemia ... : • Systemic lupus ... Antibody-mediated hemolysis
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Microcytic - Iron-deficiency ... , Liver diseases ... spherocytosis, Hemolytic ... , Liver diseases ... Schistocytes - Hemolytic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
inflammation) • Iron deficiency ... -100): • Non-hemolytic ... , CKD • Hemolytic ... , B12 deficiency ... Non-megaloblastic: Liver disease
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