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diagnosis differential hematology anemia causes algorithm clinical nephrology disease workup laboratory nutrition pathophysiology gastroenterology management rheumatology testing celiac classification dermatology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
• Microcytic - Iron-deficiency ... spherocytosis, Hemolytic ... , Thalassemia, Iron-deficiency ... cells - G-6-PD deficiency ... Schistocytes - Hemolytic
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... • Early Iron ... Deficiency #
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
inflammation) • Iron ... deficiency • ... -100): • Non-hemolytic ... , CKD • Hemolytic ... , B12 deficiency
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... Anemia - Differential ... extravascular) hemolysis ... , Copper deficiency ... #Deficiency #Anemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Thalassemia, Iron ... deficiency anemia ... Microangiopathic Hemolytic ... elliptocytosis, Severe iron ... deficiency anemia
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Deficiency Anemia ... patients with anemia ... deficiency if: ... biopsy only if serology ... #Deficiency #Anemia
Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing SUMMARY: - RDW, FEP, serum iron,
Iron Deficiency ... Anemia vs Anemia ... RDW, FEP, serum iron ... deficiency if above ... #Deficiency #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... → Sickle Cell anemia ... anemia (TTP, HUS ... #Anemia #Differential
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... • Severe B12 deficiency ... • Mechanical hemolysis ... anemia" • HELLP
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... hepcidin) • Others: Hemolysis ... , Iron metabolism ... #Deficiency #Causes ... differential #diagnosis #anemia
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