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diagnosis differential management allergy algorithm pathophysiology causes hematology classification table rheumatology shock criticalcare treatment clinical workup comparison pharmacology anesthesia checklist
Tranexamic Acid - Indications and Pharmacology Pharmacokinetics: • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
fibrinolysis (reduces complement ... w/ hereditary angioedema ... Hypersensitivity & anaphylaxis
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... dyspnea, hypoxia • Angioedema ... Urticaria • Angioedema ... #Anaphylaxis
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... • Hereditary angiooedema ... ThePeanutKidney #Complement
Clinical manifestations of anaphylaxis. Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache Angioedema: Lips, tongue, orbit,
manifestations of anaphylaxis ... doom. headache Angioedema ... incontinence #anaphylaxis
Stridor - Differential Diagnosis Framework: High-pitched, variable respiratory sound ETIOLOGIES: Infectious: • Retropharyngeal abscess • Acute epiglottitis • Peritonsillar
Allergic/Immune: • Anaphylaxis ... • Hereditary angioedema ... malformations • Anaphylaxis ... Tracheal stenosis • Anaphylaxis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
disease, hereditary angioedema ... Hypocomplementemia #Low #Complement
An Algorithm for the Diagnosis of Wheezing and Stridor Stridor: Louder, constant-pitch sound over central airways Wheezing: Musical
Inflammatory: Anaphylaxis ... , Angioedema, Epiglottitis ... Asthma, COPD, Anaphylaxis
Manifestations of Anaphylaxis by Body System Dermatologic/mucosal - Eyes: periorbital swelling/erythema, injected conjunctiva, tears - Oral mucosa:
Manifestations of Anaphylaxis ... - Oral mucosa: angioedema ... piloerection, angioedema ... Signs #Symptoms #Anaphylaxis
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 Angioedema - Classification Diagnosis and Treatment Types of Angioedema: • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... Treatment Types of Angioedema ... Acute allergic angioedema ... • Idiopathic angioedema ... • Hereditary angioedema
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
pathology: • Anaphylaxis ... Foreign body • Angioedema
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