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diagnosis hematology algorithm hemolysis causes extravascular intravascular morphology agglutinin anemias bloodcell calculation cold disease hodgkins index key lymphoma management mcv
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential ... Hemolytic Anemias ... Hemolytic Anemias ... #Anemias #Differential
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
hemolytic anemia ... hemolytic anemia ... #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... ) Morphology Atlas ... spherocytosis, Hemolytic ... key #diagnosis #differential ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Cold AIHA • Alloimmune ... elliptocytosis - RBC ... anemia • ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Defects: Sickle cell anemia ... #Differential # ... Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... hypertension • Unusual RBC ... elliptocytosis, autoimmune ... #Anemia #Differential
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... , CKD • Hemolytic ... Spherocytosis, G6PD, PK, HbC ... - Extrinsic: Autoimmune ... #Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... : Autoimmune, Microangiopathic ... hemolytic anemia ... , Intrinsic RBC ... #anemia #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... anemia • Cold ... CLL (older) • Autoimmune ... younger pts) Differential ... #anemia #hematology
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