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Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus Anti-dsDNA ... Association with disease ... Anti-histone 60 ... -15% If SLE is clinically ... with auto-immune diseases
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... ANA > - Anti-ENA ... to 30% - Anti-dsDNA ... 60% - pANCA anti-MPO ... Evolution: Chronic disease
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... findings (ANA, anti-Smith ... lymphoproliferative syndrome Clinical ... , Ro/La, anti-Jo ... for nephritis • Anti
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... ) - Anti-ENA ... ) - Anti-histone ... 40, F:M 9:1 • Clinical ... Evolution: Chronic disease
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group < 5%
cryoglobulinemia vasculitis Clinical ... - Specific anti-infectious ... the absence of anti-infectious ... with refractory disease
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... • Autoimmune diseases ... Adult-onset Still disease ... chemotherapy, anti-CD20
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibodies (ANA) ANA or Anti-NucIear ... ANA ≠ Autoimmune Disease ... likely it will be clinically ... connective tissue disease ... • Rheumatic Diseases
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
ANTI-MDA5 DERMATOMYOSITIS ... auricular papules Clinical ... : up to 74% of anti-MDA5 ... severity of the disease ... Association of Anti-MDA5
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis Clinical ... Highly variable clinical ... from subclinical disease ... ) (common, and Anti-LKM ... & Anti-ALC Abs
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Antibodies: Anti-Ro ... /SSA & Anti-La/SSB ... Antibodies: • Anti-Ro ... in primary) • Anti-La ... salivary ducts Clinical
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