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Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Antibodies: Anti-Ro ... /SSA & Anti-La/SSB ... Antibodies: • Anti-Ro ... salivary ducts Clinical ... phenomenon (16%) MSK
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... - Graves' disease ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-dsDNA (in 70% ... Anti-histone (in ... connective tissue disease ... disease - MPO>PR3 ... #rheumatology #diseases
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
60-70% - Anti-SSA ... 5-10% - Anti- ... 5-15% - Anti-Ku ... auto-immune, Infectious diseases ... sclerosis, Still's disease
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Autoantibodies Anti-topoisomerase ... I (anti-Sc170): ... Diffuse skin disease ... : Limited skin disease ... Biliary Cirrhosis Anti-RNA
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
screening test Anti-dsDNA ... with more severe disease ... activity Anti-Ro ... Sjogren syndrome Anti-UI-ribonucleoprotein ... overlap syndrome) Anti-Smith
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus Anti-dsDNA ... Association with disease ... Anti-histone 60 ... -15% If SLE is clinically ... with auto-immune diseases
Patterns of Diseases on MRI FLAIR - Differential Diagnosis ADEM, Adreno-leukodystrophy, CADASIL, CNS, Lymphoma, High-Grade Glioma, HIV
Patterns of Diseases ... , MS: Tumefactive ... Vessel Ischemic Disease ... FLAIR #Patterns #Diseases ... neuroradiology #clinical
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
vasculitis, Behcet disease ... Goodpasture's Disease ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Immunoglobulins (Anti-dsDNA ... , Anti-Sm, Anti-phospholipid ... Arthritis R Renal Disease
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