522 results
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
I (anti-Sc170): ... Diffuse skin disease ... , Pulmonary fibrosis ... : Limited skin disease ... (~93-95%), Pulmonary
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... Diagnosis for Pulmonary ... testing: anti-ANCA ... ab, anti-GBM ab
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... - Graves' disease ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% ... Anti-histone (in ... connective tissue disease ... disease - MPO>PR3 ... #rheumatology #diseases
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... Vasculitis - Anti-GBM ... Disease - Double ... Positive (ANCA + anti-GBM ... Kumfer @AnnKumfer #Pulmonary
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
60-70% - Anti-SSA ... 5-10% - Anti- ... 5-15% - Anti-Ku ... auto-immune, Infectious diseases ... sclerosis, Still's disease
General overview of lung diseases. 

#diagnosis #causes #lung #disease #restrictive #obstructive #pulmonary #respiratory #pearls #ddxof
overview of lung diseases ... #causes #lung #disease ... #obstructive #pulmonary
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... With associated pulmonary ... involvement: Anti-GBM ... Disease (Goodpasture's
Radiographic appearances of pulmonary disease in HIV-infected patients

By Dr. Sara Dong @swinndong via #IDFellowCase

#ID  #Infectious
appearances of pulmonary ... disease in HIV-infected ... ID #Infectious Diseases ... AIDS #Pneumonia #Pulmonary
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
screening test Anti-dsDNA ... with more severe disease ... activity Anti-Ro ... Sjogren syndrome Anti-UI-ribonucleoprotein ... overlap syndrome) Anti-Smith