1865 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
papules 30% w/ anti-synthetase ... Around half of anti-SRP ... and anti-HMGCR ... after 2 years of treatment ... Myositis #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
screening test Anti-dsDNA ... disease activity Anti-Ro ... overlap syndrome) Anti-Smith ... severe disease Treatment ... Summary #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
ANA > - Anti-ENA ... to 30% - Anti-dsDNA ... 60% - pANCA anti-MPO ... life-threatening • Treatment ... Management #Summary #rheumatology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
bilirubin, ↑ LDH • Anti-RBC ... diagnosis #management #treatment ... #rheumatology
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
neuropathy Treatment ... - Specific anti-infectious ... the absence of anti-infectious ... Cryoglobulinemia #Vasculitis #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
) - Anti-ENA ... ) - Anti-histone ... constitutional symptoms • Treatment ... life-threatening • Treatment ... comparison #table #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Unknown cause Treatment ... chemotherapy, anti-CD20 ... manifestations, Anti-IFN-y ... diagnosis #management #treatment ... #summary #rheumatology
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
) - Anti-ENA ... ) - Anti-histone ... constitutional symptoms • Treatment ... DrugInduced #Lupus #DIL #rheumatology ... #diagnosis #treatment
Rheumatoid Arthritis Summary
Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders
Signs & Symptoms:
rheumatoid factor) • anti-CCP ... exam and imaging Treatment ... • Biologics: Anti-TNF ... diagnosis #management #rheumatology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Treatment - Mild ... : NSAIDS Treatment ... uncontrolled: MTX, anti-TNF ... , anti-lL6R, anti-ILI ... AOSD #diagnosis #rheumatology